Therapeutic-dose heparin more likely to benefit those with less severe COVID-19 at hospitalisation, lower BMI
The benefits and harms of therapeutic-dose heparin for hospitalised patients with COVID-19 varied by patient characteristics, illustrating the importance of considering heterogeneity of treatment effect (HTE) in the design and analysis of randomised clinical trials, according to a study published in JAMA. An exploratory analysis of a multiplatform randomised trial of therapeutic-dose heparin for early-pandemic patients with moderate (n = 2,218) or severe (n = 1,102) COVID-19 found that in all 3 approaches for testing HTE (conventional subgroup analysis, risk-based analysis, and effect-based...
Pandemic stress had a greater impact on those who were pregnant, study finds
COVID-19-related stress had a greater impact on the mental health of those who were pregnant during the pandemic, compared with those who weren’t, according to a study published in JAMA Network Open. “The COVID-19 pandemic has exacerbated existing...
New Treatment Can Improve Cardiac Pump Function in Patients With Heart Failure
The hunger hormone ghrelin can increase the heart’s pump capacity in patients with heart failure, according to a study published in the European Heart Journal. “Heart failure is the most common cause of hospitalisation in older generations and is ...
