The benefits and harms of therapeutic-dose heparin for hospitalised patients with COVID-19 varied by patient characteristics, illustrating the importance of considering heterogeneity of treatment effect (HTE) in the design and analysis of randomised clinical trials, according to a study published in JAMA. An exploratory analysis of a multiplatform randomised trial of therapeutic-dose heparin for early-pandemic patients with moderate (n = 2,218) or severe (n = 1,102) COVID-19 found that in all 3 approaches for testing HTE (conventional subgroup analysis, risk-based analysis, and effect-based...
COVID-19-related stress had a greater impact on the mental health of those who were pregnant during the pandemic, compared with those who weren’t, according to a study published in JAMA Network Open. “The COVID-19 pandemic has exacerbated existing...
The hunger hormone ghrelin can increase the heart’s pump capacity in patients with heart failure, according to a study published in the European Heart Journal. “Heart failure is the most common cause of hospitalisation in older generations and is ...