BACKGROUND Type 1 diabetes increases the risk of coronary artery disease (CAD). High-throughput metabolomics may be utilized to identify metabolites associated with disease, thus, providing insight into disease pathophysiology, and serving as predictive markers in clinical practice. Urine is less tightly regulated than blood, and therefore, may enable earlier discovery of disease-associated markers. We studied urine metabolomics in relation to incident CAD in individuals with type 1 diabetes. METHODS We prospectively studied CAD in 2501 adults with type 1 diabetes from the Finnish Dia...
A risk model, developed on the basis of the differential expression of serum proteins in subclinical cardiomyopathy, accurately discriminated the risk for severe cardiomyopathy among survivors of childhood cancer, according to a study published in JA...
The US Food and Drug Administration (FDA) has approved acoramidis (Attruby) to treat adults with cardiomyopathy of wild-type or variant transthyretin-mediated amyloidosis (ATTR-CM) to reduce death and hospitalisation related to heart problems. Aco...